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  • The role of costimulation and adjuvants in the development of T cell effector and memory responses

    Creator:
    Maxwell, Joseph R.
    Abstract:
    T cells are one of the key cells in the immune system. Although they are not the first line of defense against a pathogen, their functions can greatly enhance the phagocytosis and destruction of pathogens as well as the development of antibody responses. Furthermore, even when responding T cells have...
    Resource Type:
    Dissertation
    Full Text:
    Costimulation and Adjuvants in the Development of T Cell Effector and Memory Responses. Abstract approved

  • An Investigation into the Functional Properties of the Deafness Causing Protein Otoferlin

    Creator:
    Manchanda, Aayushi
    Abstract:
    Otoferlin is a C2-domain, transmembrane protein whose mutated form is responsible for the DFNB9 subtype of prelingual hearing impairment. Mutations in otoferlin cause an autosomal recessive, non-syndromic form of deafness that is characterized by auditory neuropathy/ auditory dissynchrony (AN/AD), meaning that the outer hair cells (OHCs) are normal, and the...
    Resource Type:
    Dissertation
    Full Text:
    . Johnson Abstract Otoferlin is a C2-domain, transmembrane protein whose mutated form is

  • Relationship between rate of torque development and contractile impulse in three muscle groups

    Creator:
    Wright, Jaime M.
    Abstract:
    Background: The capability of an individual to produce force rapidly is important for performance of sporting activities and to stabilize a joint to protect against injury. Rate of torque development (RTD) and contractile impulse (CI) may be more effective than peak torque in assessing rapid torque production. The relationship between...
    Resource Type:
    Honors College Thesis
    Full Text:
    history. Clin Biomech 25: 450–454, 2010. 6. Chang E, Norcross MF, Johnson ST, Kitagawa T, Hoffman M

  • Vitamin E and K interactions : investigating mechanisms of reduced vitamin K status in response to excess vitamin E

    Creator:
    Farley, Sherry Mae
    Abstract:
    The primary goal of my studies was to elucidate the mechanisms for the well-recognized interaction between two nutrients, vitamins E and K. The outcomes from my studies assess mechanisms for adverse effects of vitamin E and provide novel information on mechanisms for vitamin K homeostasis. These findings will provide information...
    Resource Type:
    Dissertation
    Full Text:
    no increases in urinary vitamin K catabolites were found. Chapter 4 shows that -T-injected rats

  • Uncovering the mechanism of IL-4-mediated T cell survival

    Creator:
    Moscibrocki, Cathleen M.
    Abstract:
    Although IL-4 is a well-characterized multi-functional cytokine, its role as a survival factor in T cells is not completely understood. In an attempt to uncover IL-4-mediated survival, we studied caspase activation in primary mouse T lymphocytes undergoing death by neglect, activation-induced or steroid-induced cell death. Here, we identify the executioner...
    Resource Type:
    Masters Thesis
    Full Text:
    Mechanism of IL-4-mediated T Cell Survival by Cathleen M. Moscibrocki A THESIS submitted to Oregon State

  • The influence of aryl hydrocarbon receptor activation on T cell fate

    Creator:
    Funatake, Castle J.
    Abstract:
    2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds are well-recognized for their immunosuppressive activity, which is mediated through an intracellular receptor and transcription factor, aryl hydrocarbon receptor (AhR). Laboratory animals exposed to TCDD are less resistant to infection and have severely impaired humoral and cell-mediated immune responses. This dissertation addressed the hypothesis that...
    Resource Type:
    Dissertation
    Full Text:
    Hydrocarbon Receptor Activation on T Cell Fate. approved: 2,3,7, 8-Tetrachlorodibenzo-p-dioxin (TCDD) and

  • Very high physical activity predicts higher diet quality in healthy young adults, as measured by the Healthy Eating Index 2005

    Creator:
    Johnson, Angela K.
    Abstract:
    Physical inactivity and unhealthful diet are major risk factors for noncommunicable diseases, and strategies worldwide now focus on improving diet and encouraging physical activity (PA). Participation in PA lowers the risk for numerous chronic diseases, while a healthful diet also offers resistance to disease. However, practicing both behaviors offers greater...
    Resource Type:
    Masters Thesis
    Full Text:
    AN ABSTRACT OF THE THESIS OF Angela K. Johnson for

  • Spinal Motor Control Adaptations to Explosive Strength Training

    Creator:
    Stone, Clara A.
    Abstract:
    The nervous system has an integral role in rapid torque production of the lower extremity, which is often necessary for proper motor response to a dynamic environment. The nervous system is complex with numerous pathways, including spinal motor control networks, which influence the ability to move. However, few studies have...
    Resource Type:
    Masters Thesis
    Full Text:
    approved: ______________________________________________________ Samuel T. Johnson The

  • Developing a Qualitative Assessment Instrument to Measure Conceptualization of Oppression and Privilege

    Creator:
    Johnson, Rachel M.
    Abstract:
    An understanding of oppression and privilege would improve engineering climates and encourage individuals with marginalized identities to stay engaged in engineering spaces. Currently there are quantitative tools to assess cultural competencies, but none that measure understandings of power relationships. This project aims to create a qualitative assessment instrument to measure...
    Resource Type:
    Honors College Thesis
    Full Text:
    Michelle Johnson A THESIS submitted to Oregon State University Honors

  • Evaluating balance and strength of older women in exercise programs

    Creator:
    Dinger, Melanie
    Abstract:
    Falls are a common problem among older adults, including those who are relatively healthy and living independently. Exercise has been recommended as an intervention to reduce falls by slowing and/or reversing age-related declines in balance, strength, and mobility. However, it remains unclear which types or combinations of programs are most...
    Resource Type:
    Masters Thesis
    Full Text:
    References Blake, A. J., Morgan, K., Bendall, M. J., Dallosso, H., Ebrahim, S. B. J., Arie, T. H. D