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Total Synthesis of Tryptamine Alkaloids from the Arundo and Leuconotis Genera

Creator:

Ferreira, Andrew

Abstract:

The first part of this manuscript is about the total synthesis of the Arundo donax bis(indole) natural products. The A. donax alkaloids were prepared using the first example of an ynindole Diels–Alder reaction. Each were then separated, isolated, and determined to have stable enantiomeric conformations at room temperature (Chen, J.;...

Resource Type:

Dissertation

Full Text:

enantiomeric conformations at room temperature (Chen, J.; Ferreira, A. J.; Beaudry, C. M. Angew. Chem. Int
Syntheses and evaluation of putative enzyme inhibitor of isoprenoid biosynthesis

Creator:

Phaosiri, Chanokporn

Abstract:

The discovery of the methylerythritol phosphate pathway (the MEP pathway) as an alternate pathway for isoprenoid biosynthesis in some organisms including most bacteria, malarial parasites and plants, but not in animals, has stimulated extensive studies in this area. Research has revealed the potential of finding novel antibacterials, antimalarial drugs, and...

Resource Type:

Dissertation

Full Text:

ethylerythritol triacetate derivative from the enzymatic reaction. C). Co-injection of synthetic and enzymatically
Studies toward the total synthesis of (+)-providencin

Creator:

Jana, Somnath

Abstract:

Studies toward the total synthesis of (+)-providencin (1), a highly oxygenated cembranoid dipterpene with a unique bicyclo[12.2.0]hexadecane skeleton and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediates 320 and 332 which contain all of the carbon atoms of 1. In a first generation approach...

Resource Type:

Dissertation

Full Text:

to couple the two major fragments, 228 and 288, using palladium-catalyzed C-H activation of the