Tuberculosis (TB) is a pressing global health issue with approximately one third of the world’s population infected by this bacterium. As one of the most dangerous infectious diseases, it has killed approximately 1.7 million people of all ages around the world per year (World Health Organization, 2016). Currently, several drugs...
Mensacarcin is a stereogenic complex polyketide with potent anti-tumor activity produced by a soil-dwelling Streptomyces bottropensis. The US National Cancer Institute (NCI) 60 human tumor cell line anticancer drug screen (NCI-60) reveals mensacarcin’s cytostatic properties in almost all tested cell lines and distinct cytotoxic properties specifically in eight melanoma cell...
Exploring bioactive natural products has contributed largely to clinically approved drugs we have been using over the last 100 years. Especially among the anti-infective drugs, around 70% of currently used antibiotics were discovered or derived from microbial secondary metabolites, among them compounds like vancomycin, chloramphenicol, and erythromycin. Facing the unavoidable...
Prior to eruption at mid-ocean ridges, melts must travel through >6 km of crust from their origin in the mantle. The final composition of the melts is dependent on both the melting conditions and magmatic processes within the crust. While mid-ocean ridge basalt (MORB) glasses are commonly used to infer...
Up to 99.9% of native North American grasslands have been degraded since European settlement, primarily due to agricultural conversion. Today, grasslands are a top priority for restoration as they provide essential habitat for many rare and endangered species; however, the majority of studies in grasslands have focused on vegetation or...
In a story of his life Les reflects on what he
has gained and what he has lost while seeking success in
the moving and shifting of military and academic life
through homes and schools all over the United States.
He describes himself as between races, languages, and
cultures.
A sensory method was developed to determine cheese texture by hand evaluation. Cheese sensory evaluation was conducted by panelists (n=8) on four commercial samples in duplicates. Standards, descriptors, methods of each attribute evaluation, sample size, and ballot were developed based on panelists' consensus. Fifteen total attributes, divided into five groups,...
Vineyards in Oregon’s Willamette Valley are predominately planted to perennial grass cover in the alleyways of vineyards. This grass cover is grown to increase worker and equipment traction, as well as reduce erosion and manage vine vegetative vigor. However, with increasing frequencies of drought and warming temperatures, the use of...
Because of disease, industrialization, and regional conflicts, young widowhood is an expanding phenomenon in many parts of the world. Young widows face many challenges that can lead to mental health problems. The young widows have to make adjustments to fit their new roles as bread winners of the families, having...
A challenge for municipal authorities of growing urban areas is to provide larger and faster transportation and utility networks that are safe and resilient to significant disruptions after an earthquake event and other disasters. Urban regions, like the San Francisco Bay or the Los Angeles area, are situated in seismically...