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  • Control of p53 tumor suppressor and peroxiredoxin activity through shifts incellular redox balance

    Creator:
    Stoner, Christopher S.
    Abstract:
    Aerobic organisms have evolved many sensory mechanisms that allow response to oxidants in the environment. One area of interest is the relationship between the activity of the tumor suppressor protein p53 and the redox state of thioredoxin. Human p53 activity is severely compromised in budding yeast lacking thioredoxin reductase. Evidence...
    Resource Type:
    Dissertation
    Full Text:
    Peroxiredoxin Activity Through Shifts in Cellular Redox Balance Abstract approved: Gary F

  • Identifying the Enzymes Responsible for Reduction of Doxorubicin to its Cardiotoxic Metabolite Doxorubicinol using a Novel Immunoclearing Approach

    Creator:
    Breysse, Daniel H.
    Abstract:
    Doxorubicin is a widely used cancer therapeutic, but its effectiveness is limited by cardiotoxic side effects. Evidence suggests cardiotoxicity is due not to doxorubicin, but rather its metabolite, doxorubicinol. Identification of the enzymes responsible for doxorubicinol formation is important in developing strategies to prevent cardiotoxicity. In this study, the contributions...
    Resource Type:
    Masters Thesis
    Full Text:
    : ______________________________________________________ Gary F. Merrill Doxorubicin is a widely used cancer therapeutic, but its

  • Magnetotelluric Constraints on Lithospheric Properties in the Southeastern United States

    Creator:
    Murphy, Benjamin S.
    Abstract:
    By inverting EarthScope long-period magnetotelluric (MT) data from the southeastern United States (SEUS), we obtain electrical conductivity images that provides key insights into the geodynamics of this region. Significantly, we resolve a highly electrically resistive block that extends to mantle depths beneath the modern Piedmont and Coastal Plain physiographic provinces....
    Resource Type:
    Dissertation
    Full Text:
    approved: _______________________________________________________ Gary D. Egbert By

  • Hydrothermal links between ocean plateau formation and global anoxia at the Cenomanian-Turonian boundary

    Creator:
    Snow, Laura J.
    Abstract:
    The Cretaceous was a period of extreme climatic conditions accompanied by major perturbations in ocean-atmosphere biogeochemical cycles. One of the most intriguing features is the sporadic interruption of normal marine pelagic sediment deposition by organic rich sediments deposited during oxygen-deficient conditions (ocean anoxic events OAEs). A current model for the...
    Resource Type:
    Masters Thesis
    Full Text:
    AN ABSTRACT OF THE THESIS OF Laura J. Snow for the degree of

  • Butterflies of the H.J. Andrews Experimental Forest : biological inventory and ecological analysis

    Creator:
    Ross, Dana N. R.
    Abstract:
    A biological inventory of the butterflies of the H. J. Andrews Experimental Forest [HJA] in Linn/Lane County, Oregon was conducted during 1994 and 1995. It was the first comprehensive survey of HJA butterflies for the site and serves as a baseline for future butterfly research. A detailed ecological account is...
    Resource Type:
    Masters Thesis
    Full Text:
    Master of Science in Entomology presented on October 31, 2003. Butterflies of the H. J. Andrews

  • The Effects of Social Media on The Human Psyche

    Creator:
    Hall, Keenan P.
    Abstract:
    This thesis is a study of the effects of social media and the influence it has over people and their wellbeing. The study within the thesis manipulates the social media habits of Oregon State students, and looks at the changes in their wellbeing. Throughout the background research the evidence supports...
    Resource Type:
    Honors College Thesis
    Full Text:
    Human Psyche Abstract approved:_____________________________________________________ Gary Micheau

  • Common Factors that Affect Aesthetics in Bridge Design

    Creator:
    Coe, Jennifer J.
    Abstract:
    Aesthetics should be emphasized as much as possible in a design project without exceeding scope, budget, or schedule to satisfy the stakeholders involved. There is a rising trend of increased emphasis on aesthetics. This trend of using various techniques to help structures blend in or contribute to the surrounding environment...
    Resource Type:
    Honors College Thesis
    Full Text:
    Jennifer J. Coe for the degree of Honors Baccalaureate of Science in Civil Engineering presented on May 19

  • Evaluation of remediation techniques for circular holes in the webs of wood I-joists

    Creator:
    Polocoser, Tiberiu
    Abstract:
    The objective of this project was to evaluate methods to remediate a wood I-joist with a single, circular hole in the web while leaving utilities in place. The methods were experimentally evaluated with a full-scale bending test using four equally spaced point loads. There were three depths of joists with...
    Resource Type:
    Masters Thesis
    Full Text:
    Abstract approved: Rakesh Gupta Thomas H. Miller The objective of this project was

  • Ground dwelling beetles in early and late successional forests in the western Cascades of Oregon

    Creator:
    Heyborne, William H.
    Abstract:
    The effects of forest cutting on forested systems and the biotic components of those systems has been at the forefront of scientific research. The inventory and monitoring of biodiversity is one technique used for measuring the effects of forest management. Because bioinventory studies are expensive, indicator species are often sought...
    Resource Type:
    Masters Thesis
    Full Text:
    . Miller The effects of forest cutting on forested systems and the biotic components of those systems has

  • Performance of wood frame wall with thin shell ECC shear panel

    Creator:
    Lewis, Michael C.
    Abstract:
    The overall goal of this study was to evaluate an alternative to traditional wood framed shear wall construction. This study introduced the innovative idea of using a water and seismic damage resistant, wood-concrete- composite (WCC) construction instead of an all-wood design. The WCC design consisted of a thin shell of...
    Resource Type:
    Masters Thesis
    Full Text:
    Thomas H. Miller The overall goal of this study was to evaluate an