Determination of the gross edge of a tumor is required during patient staging, assessing response to therapy, and for planning and executing surgical resection of locally invasive neoplasms. Disagreement in determination of the gross edge of the tumor is likely to directly affect patient staging, assessing response to therapy and...
Feline injection site sarcomas (FISS) are frequently encountered cutaneous and subcutaneous neoplasms of cats. Significant patient morbidity is related to the invasiveness these tumors display, typically requiring extensive local excision or amputation. As with many veterinary tumors, survival time and tumor recurrence for FISS is highly influenced by histologic margin...
This thesis presents two related studies on the methodology for creating, and
subsequently analyzing, an inverse food web model of an intertidal seagrass bed. The first study (Chapter 2) describes, for the first time in the literature, a method for incorporating isotopic information gained from Bayesian mixing models into an...
Platelet-rich plasma (PRP) has been applied as a hemostatic agent since the 1970s, and a potent source of autologous growth factors since the 1990s. PRP is rich in growth factors such as platelet derived growth factor (PDGF), vascular endothelial growth factor (VEGF), transforming growth factor-β (TGF-β), fibroblast growth factor (FGF)...
Availability of suitable nesting habitat that is free of nest predators and provides access to adequate prey resources within commuting distance is a major factor limiting seabird populations. Caspian terns (Hydroprogne caspia) in western North America have shifted their breeding habitat from naturally occurring habitats in interior wetlands, lakes, and...
Background:
Canine oral fibrosarcoma (COF) is one of the most common oral tumors in dogs and carries a guarded prognosis due to a lack of effective systemic therapeutic options. Mastinib and imatinib are two commonly used tyrosine kinase inhibitors (TKIs) in veterinary oncology but their potential efficacy against COF is...
Background: Osteosarcoma (OSA) is the most common primary bone tumor of dogs and carries a poor prognosis
despite aggressive treatment. An improved understanding of the biology of OSA is critically needed to allow for
development of novel diagnostic, prognostic, and therapeutic tools. The surface-exposed proteome (SEP) of a
cancerous cell...
Image-guided phototherapy is extensively considered as a promising therapy for cancer treatment. To enhance translational potential of this modality, we developed a single agent-based biocompatible nanoplatform that provides both real time near-infrared (NIR) fluorescence imaging and combinatorial phototherapy with dual photothermal and photodynamic therapeutic mechanisms. The developed theranostic nanoplatform consists...
Mass Spectrometry has emerged as an analytical core technique in omics sciences, in particularly mass spectrometry has advanced the fields of proteomics, metabolomics and lipidomics in recent years. Mass spectrometric techniques have enabled the characterization and determination of abundance levels of a wide range of biomolecules at molecular and system-wide...
OSU Libraries & Press initiated a pilot Open Access Fund in April 2015 that paid for open access article processing charges for OSU authors who met award criteria. The purpose of the fund was to heighten the visibility and accessibility of OSU scholarship and to support faculty and their student...