This thesis describes in-vitro and in-vivo evaluation of a transdermal atenolol formulation developed at Oregon State University, College of Pharmacy. The formulation was prepared from carbomer as a gel base with propylene glycol, glycerol, ethanol, polysorbate 80 and dimethyl-isosorbide (DMI) as mixture of penetration enhancing agents. The effect of the...
Minimal research has focused on the social dimension of sustainability in the built environment especially as it relates to the construction workforce. As a result, there are few to no tools available to industry stakeholders to holistically assess and improve the social sustainability of the construction workforce. Given the high...
Introduction: Youth in foster care face greater rates of trauma and subsequent mental health challenges (Bruce et al., 2009; O’Neill et al., 2012; Seltzer et al., 2012; etc.) that place increased burden on their caregivers (Daniel, 2011; McKeough et al., 2017), suggesting that these specific groups of youth in foster...
My dissertation title is, “Applied economic strategies to evaluate policies and environmental outcomes: case studies from immigration and ecosystem services.” The first two chapters of this dissertation concern the relationship between local immigration policies and societal welfare. The third chapter examines the impact of human activity on the environment and...
Despite the dissemination of comprehensive reviews and teacher-friendly resources describing evidence-based practices to improve student outcomes, the adoption of these practices is slow and inconsistent across instructors at colleges and universities. To help reduce this research-practice gap, I argue for the application of implementation science to teaching and learning research...
The COVID-19 pandemic has shed a light on the need for people to trust in medical science. With the need for 70% of Americans to be vaccinated to achieve herd immunity but 30% have reported vaccine hesitancy, now more than ever do we need to redouble our efforts to ensure...
Small molecule drugs have been instrumental in our fight against diseases, beginning when some of the earliest ancient cultures used plant remedies to treat illnesses. More recently, the skill of isolating and characterizing the active ingredients within bioactive plants and microbial extracts has led to the isolation and design of...
Intracellular delivery of mRNA holds great potential for vaccine and therapeutic discovery and development. This is realized by the preeminent role mRNA is playing in the record-breaking pace of SARS-CoV-19 vaccine development. Recent advances in chemical modifications of mRNA have enabled high-efficiency gene expression with superior spatiotemporal control while eliminating...
Natural durability remains one of the most attractive characteristics of wood, and helps wood obtain a premium price. A worldwide shift towards the use of younger trees from intensively managed forests has created greater concerns about wood quality, especially the wood’s resistance to fungi and insects. Wood durability is assessed...
The Altar Valley is an important working landscape that supports biodiversity and vulnerable species in Pima County, Arizona (Huckelberry 2000). This semi-desert grassland, alluvial valley and 713,807-acre watershed composed of 39 subbasins serves as an aquifer to a portion of southwestern Tucson. This region of Southern Arizona has been identified...