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Boosting Intracellular Delivery of mRNA Therapeutics

Creator:

Patel, Siddharth D.

Abstract:

Intracellular delivery of mRNA holds great potential for vaccine and therapeutic discovery and development. This is realized by the preeminent role mRNA is playing in the record-breaking pace of SARS-CoV-19 vaccine development. Recent advances in chemical modifications of mRNA have enabled high-efficiency gene expression with superior spatiotemporal control while eliminating...

Resource Type:

Dissertation

Full Text:

electrostatic complexation to package nucleic into nanoparticles using cationic lipids (e.g. 1,2-di-O
Design and Analysis of Free-space Optical Communications Systems for Next Generation Short-range Wireless Networks

Creator:

Liverman, Spencer

Abstract:

This dissertation focuses on indoor free-space optical communications systems for use in short range wireless networks. We propose that current radio frequency wireless links be augmented or replaced with optical frequency links due to overcrowding in the radio frequency spectrum. Optical frequencies contain hundreds of terahertz of unregulated bandwidth and...

Resource Type:

Dissertation
Early post-restoration recovery of tidal wetland structure and function at the Southern Flow Corridor project, Tillamook Bay, Oregon

Creator:

Janousek, Christopher, Bailey, Scott, van de Wetering, Stan, Brophy, Laura, Bridgham, Scott, Schultz, Matthew, and Tice-Lewis, Maxwell

Abstract:

A substantial fraction of estuarine tidal wetlands have been lost to development or other human uses in the Pacific Northwest since the 1800s. Wetland restoration, typically through tidal re-connection, can restore normal tidal hydrology to these areas and improve estuarine capacity to support ecosystem functions and services. Restoration may initiate...

Resource Type:

Technical Report