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  • A Panel of Histone H3 Mutations to Investigate Centromere Maintenance and Gene Silencing

    Creator:
    Geisler, Mark S.
    Abstract:
    Histones, as part of nucleosomes, are responsible for DNA packaging in chromosomes. They also affect DNA expression by a multitude of post-translational modifications, especially prevalent on the amino terminus of histones. Co-activator protein complexes “write”, “read”, or “erase” histone modifications, and in balance determine which sections of DNA are free...
    Resource Type:
    Honors College Thesis
    Full Text:
    , Madison Esposito, Steven Friedman, Rodrigo Gonçalves, and Michael Freitag conceived and designed the