Index Catalog // ScholarsArchive@OSU

Creator:: Patel, Siddharth D.
Abstract:: Intracellular delivery of mRNA holds great potential for vaccine and therapeutic discovery and development. This is realized by the preeminent role mRNA is playing in the record-breaking pace of SARS-CoV-19 vaccine development. Recent advances in chemical modifications of mRNA have enabled high-efficiency gene expression with superior spatiotemporal control while eliminating...
Resource Type:: Dissertation
Full Text:: applications that are directed towards retinal reprogramming or genome editing. Overall, non-viral delivery

Creator:: Geisler, Mark S.
Abstract:: Histones, as part of nucleosomes, are responsible for DNA packaging in chromosomes. They also affect DNA expression by a multitude of post-translational modifications, especially prevalent on the amino terminus of histones. Co-activator protein complexes “write”, “read”, or “erase” histone modifications, and in balance determine which sections of DNA are free...
Resource Type:: Honors College Thesis
Full Text:: , every cell in an organism contains the same genetic material, the sum of which comprises its genome

Creator:: Clark, Erica Jennifer
Abstract:: Pacific salmon are an integral part of ecosystems, industry, culture, and food source. Rapid declines and extirpation in many populations and species have caught the interest of environmentalists, scientists, recreational anglers, commercial fishers, general public, and economists. Billions of dollars have been spent to restore, return, improve, sustain dwindling populations...
Resource Type:: Capstone Project
Full Text:: study evaluates the research type and methods used to assess restoration efforts of anadromous

Creator:: Overacker, Ross D.
Abstract:: Small molecule drugs have been instrumental in our fight against diseases, beginning when some of the earliest ancient cultures used plant remedies to treat illnesses. More recently, the skill of isolating and characterizing the active ingredients within bioactive plants and microbial extracts has led to the isolation and design of...
Resource Type:: Dissertation
Full Text:: diseases with unmet therapeutic needs. The research discussed here is presented over three chapters. In

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