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Filtering by: Creator Mooney, Harold A. Remove constraint Creator: Mooney, Harold A. Rights Statement In Copyright - Educational Use Permitted Remove constraint Rights Statement: In Copyright - Educational Use Permitted

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  • A three-dimensional mapping of the ocean based on environmental data

    Creator:
    Wright, Dawn J.
    Abstract:
    The existence, sources, distribution, circulation, and physicochemical nature of macroscale oceanic water bodies have long been a focus of oceanographic inquiry. Building on that work, this paper describes an objectively derived and globally comprehensive set of 37 distinct volumetric region units, called ecological marine units (EMUs). They are constructed on...
    Resource Type:
    Article
    Full Text:
    sayre_resubmit_ms 1 Title: 1 A three-dimensional

  • Boosting Intracellular Delivery of mRNA Therapeutics

    Creator:
    Patel, Siddharth D.
    Abstract:
    Intracellular delivery of mRNA holds great potential for vaccine and therapeutic discovery and development. This is realized by the preeminent role mRNA is playing in the record-breaking pace of SARS-CoV-19 vaccine development. Recent advances in chemical modifications of mRNA have enabled high-efficiency gene expression with superior spatiotemporal control while eliminating...
    Resource Type:
    Dissertation
    Full Text:
    this thesis, we study subcellular barriers to LNP-delivered mRNA and screen a unique class of