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  • Boosting Intracellular Delivery of mRNA Therapeutics

    Creator:
    Patel, Siddharth D.
    Abstract:
    Intracellular delivery of mRNA holds great potential for vaccine and therapeutic discovery and development. This is realized by the preeminent role mRNA is playing in the record-breaking pace of SARS-CoV-19 vaccine development. Recent advances in chemical modifications of mRNA have enabled high-efficiency gene expression with superior spatiotemporal control while eliminating...
    Resource Type:
    Dissertation
    Full Text:
    spherical LNPs, while x-ray scattering shows little disparity in internal structure. eLNPs exhibit higher

  • Transdermal Delivery of Atenolol to Cats

    Creator:
    Mohamed, Sumeia M.
    Abstract:
    This thesis describes in-vitro and in-vivo evaluation of a transdermal atenolol formulation developed at Oregon State University, College of Pharmacy. The formulation was prepared from carbomer as a gel base with propylene glycol, glycerol, ethanol, polysorbate 80 and dimethyl-isosorbide (DMI) as mixture of penetration enhancing agents. The effect of the...
    Resource Type:
    Dissertation

  • Timescales and tectonics of oceanic plateaus : long-term evolution of Ontong Java Nui and Rio Grande Rise

    Creator:
    Davidson, Peter C.
    Abstract:
    Oceanic plateaus are regions of overthickened oceanic crust and are often thought to form from the interaction of mantle plumes with oceanic lithosphere. These regions can cover vast areas of the ocean basins and represent a highly elevated magmatic flux relative to normal mid-ocean ridge spreading. Oceanic plateaus are considered...
    Resource Type:
    Dissertation
    Full Text:
    Frey, F.A., Coffin, M.F., Wallace, P.J., Weis, D., Zhao, X., Wise, S.W., Wähnert, V., Teagle, D.A.H