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Investigating the Mechanisms for the Effects of Nitrate Treatment on Exercise Performance and Energy Metabolism

Creator:

Keller, Rosa M.

Abstract:

Dietary nitrate (NO3-), consumed primarily from leafy green and root vegetables, lowers blood pressure, improves vascular function and aerobic exercise performance. This performance-enhancing effect of nitrate supplementation is largely attributed to the increased bioavailability of the signaling molecule, nitric oxide (NO). Nitric oxide is a ubiquitous free radical signaling molecule...

Resource Type:

Dissertation

Full Text:

Johnson, Mary Catherine Prater, Manuel Garcia-Jaramillo, Matt Robinson, Patrick Reardon, Robyn Tanguay
Computational Approaches for Understanding Combinatorial Gene Regulation

Creator:

Ansariola, Mitra

Abstract:

Gene regulation is a complex mechanism that controls the spatial and temporal expression of genes in a living cell. My dissertation studies focus on two problems. First, tissue-specific gene expression prediction from DNA sequence and chromatin state, and second, the accurate discovery of small over-represented regulatory circuits in gene regulatory...

Resource Type:

Dissertation
Machine Learning for Precision Medicine: Application to Cancer Chemotherapy Response Prediction and Wound Healing Status Assessment

Creator:

Wei, Qi

Abstract:

Ph.D. candidate Qi Wei's thesis consists of two projects: Chemotherapy Project: a study based on the research paper "Predicting chemotherapy response of various cancer types using a variational auto-encoder approach" submitted to the bioRxiv preprint archive and accepted by the BMC bioinformatics; and Wound Monitor Project: implementing and assessing analytics...

Resource Type:

Dissertation

Full Text:

studied in the context of chemotherapy pharmacokinetics [80, 67, 12]. In sum- mary the ability to