Vitamin E improved liver histology in children and adults with NAFLD who participated in TONIC and PIVENS clinical trials,
but with significant inter-individual variability in its efficacy. Cytochrome P450 4F2 (CYP4F2) is the major enzyme
metabolizing Vit E, with two common genetic variants (V433M, rs2108622 and W12G, rs3093105) found to...
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Cynthia Fleming, RN, MSN; Marwan Ghabril, MD; Ann Klipsch, RN;
Smitha Marri, MD; Jean P. Molleston, MD