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  • The asymmetric binding of Actinomycin D to DNA hexamers

    Creator:
    Ivancic, Monika
    Abstract:
    The solution structure determination of DNA molecules has been an important part of structural biology. NMR solution structures are a complement to structures solved via X-ray crystallography; the two methods are the only ways of obtaining three dimensional coordinates of macromolecules. Because of the nature of the molecule, the solution...
    Resource Type:
    Dissertation
    Full Text:
    examined using NMR spectroscopy, including drug-bound DNA complexes. Most previous studies of complexes