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Filtering by: Subject Anticonvulsants Subject Adenosine -- Physiological effect

Adenosine analogs suppress seizures induced by bicuculline methiodide in the rat prepiriform cortex

Creator:

Zhang, Ge

Abstract:

Although considerable experimental evidence suggests that endogenous adenosine may function as a modulator of neuronal activity in the etiology or control of seizures, the neuroanatomical and neurochemical basis for the anticonvulsant actions of adenosine have not been well established. A discrete brain region of possible fundamental importance to epileptogenisis within...

Resource Type:

Masters Thesis

Full Text:

and neurochemical basis for the anticonvulsant actions of adenosine have not been well established
Activation of adenosine receptors in prepiriform cortex modulates seizure susceptibility

Creator:

Zhang, Ge, 1956-

Resource Type:

Dissertation

Full Text:

study was to characterize the anticonvulsant actions mediated by activation of the adenosine receptor
Adenosine receptor modulation of seizure susceptibility in rats

Creator:

Szot, Patricia

Abstract:

Adenosine is considered to be a neuromodulator or cotransmitter in the periphery and CNS. This neuromodulatory action of adenosine may be observed as an anticonvulsant effect. Dose-response curves for R-phenylisopropyladenosine (PIA), cyclohexyladenosine (CHA), 2-chloroadenosine (2-ClAdo), Nethylcarboxamidoadenosine (NECA) and S-PIA were generated against PTZ seizure thresholds in the rat. The rank...

Resource Type:

Dissertation

Full Text:

observed as an anticonvulsant effect. Dose-response curves for R-phenylisopropyladenosine (PIA