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Filtering by: Creator Hong, Keum-Shik Subject Aging -- Genetic aspects

Age-related alterations in transcriptional regulation of hepatic glutathione synthesis : remediation by R-alpha-lipoic acid

Creator:

Shenvi, Swapna V.

Abstract:

Glutathione (GSH) is the predominant low molecular weight thiol antioxidant in liver tissue. GSH plays an important role in maintaining the intracellular thiol redox ratio as well as detoxification of electrophiles and xenobiotics. Aging leads to a significant decline (35%; P ≤ 0.05) in hepatocellular GSH levels. Using young (2-4...

Resource Type:

Dissertation

Full Text:

and activity as well as hepatic GSH content. In this chapter, Drs. Hong Wang and Rui-Ming Liu were