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Filtering by: Committee Member Thompson, M. Paul Subject Alkaloids -- Synthesis

A unified approach for the total synthesis of C₁₀-functionalyzed Lycopodium alkaloids

Creator:

Saha, Mrinmoy

Abstract:

Lycopodium alkaloids have shown widespread and noteworthy biological activity, consisting of over 250 known natural products. Moreover, their structural complexity and diversity have attracted considerable attention from numerous laboratories including our own. Recently, we have developed a unified approach that would provides access to numerous, previously unprepared C₁₀-functionalized lycopodium alkaloids....

Resource Type:

Dissertation

Full Text:

) Nikonorow, M. Acta Polon. Pharm. 1939, 3, 23-56. (d) Ortega, M. G.; Agnese, A. M.; Cabrera, J. L
Enantioselective Total Syntheses of Quinolizidine Lycopodium Alkaloid Cermizine D and Cytotoxic Marine Macrolide Mandelalide A

Creator:

Veerasamy, Nagarathanam

Abstract:

The enantioselective total synthesis of quinolizidine-containing natural product cermizine D and formal syntheses of senepodine G and cermizine C has been achieved. These natural products are members of the lycopodium alkaloids, which have attracted significant attention due to their exciting biological activities and the diverse structural scaffolds. Key steps in...

Resource Type:

Dissertation

Full Text:

.) THF, 60 °C; 3 M HCl in MeOH 98% N H Cl NaBH4, MeOH 99% N H (-)-Cermizine C (1.9) 1.1.1 1.1.3