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Filtering by: Committee Member Kolluri, Siva Kumar Remove constraint Committee Member: Kolluri, Siva Kumar Subject Antibiotics -- Development Remove constraint Subject: Antibiotics -- Development

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  • Evaluation of peptide phosphorodiamidate morpholino oligomers as a novel antibiotic therapy

    Creator:
    Kaller, Margo
    Abstract:
    Peptide-phosphorodiamidate morpholino oligomers (PPMOs) are synthetic DNA mimics that bind and silence gene targets. Through designing PPMOs that silence essential or resistance genes in pathogens, these antisense oligomers could be utilized as novel antimicrobials. Towards this end, my thesis employed minimum inhibitory concentration assays (MICs) to identify PPMOs capable of...
    Resource Type:
    Masters Thesis
    Full Text:
    as well! Dr. Siva Kolluri’s class on molecular therapeutics was a formative experience for my