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Filtering by: Committee Member Mcphail, Kerry Remove constraint Committee Member: Mcphail, Kerry Subject Antibiotics -- Synthesis Remove constraint Subject: Antibiotics -- Synthesis

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  • Biosynthetic engineering of new pactamycins

    Creator:
    Lu, Wanli
    Abstract:
    Among the myriad of naturally occurring bioactive compounds are the aminocyclopentitol-containing natural products that represent a family of sugar-derived microbial secondary metabolites, such as the antibiotics pactamycin, allosamidin, and trehazolin. Pactamycin, a structurally unique aminocyclitol antibiotic isolated from Streptomyces pactum, consists of a 5-membered ring aminocyclitol (cyclopentitol) unit, two aromatic...
    Resource Type:
    Dissertation
    Full Text:
    . Mark Zabriskie, Dr. Arup Indra, Dr. Xihou Yin, and Dr. Kerry McPhail for their valuable time and

  • Biosynthesis and modification of the antibiotic enduracidin

    Creator:
    Goebel, Neal C.
    Abstract:
    The continued propagation of antibiotic resistance requires the development of new therapeutics. The lipopeptide antibiotic enduracidin has demonstrated high activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus. In addition to a lack of cross-resistance with existing antibiotic classes, enduracidin has no known transferrable resistance mechanism. The development of enduracidin as...
    Resource Type:
    Dissertation
    Full Text:
    Mahmud. Phil Proteau and Kerry McPhail. It has been a privilege to have worked with you. The advice and