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Filtering by: Advisor Zabriskie, Mark Remove constraint Advisor: Zabriskie, Mark Subject Antibiotics -- Synthesis Remove constraint Subject: Antibiotics -- Synthesis

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  • Biosynthesis and modification of the antibiotic enduracidin

    Creator:
    Goebel, Neal C.
    Abstract:
    The continued propagation of antibiotic resistance requires the development of new therapeutics. The lipopeptide antibiotic enduracidin has demonstrated high activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus. In addition to a lack of cross-resistance with existing antibiotic classes, enduracidin has no known transferrable resistance mechanism. The development of enduracidin as...
    Resource Type:
    Dissertation
    Full Text:
    , mentoring and guidance provided by my advisor Dr. Mark Zabriskie. He has provided me with the opportunity

  • Advanced studies on the biosynthesis of the streptolidine moiety of streptothricin F

    Creator:
    Jackson, Michael D.
    Resource Type:
    Dissertation
    Full Text:
    Streptolidine Moiety of Streptothricin F Abstract T. Mark Zabriskie Streptothricin F (STF, 12a) is a peptidyl

  • Formation and modification of enduracididine, a nonproteinogenic amino acid

    Creator:
    Tan, Ying
    Abstract:
    Molecular genetic and enzymological techniques have been employed to study antibiotic biosynthesis. In this thesis, we studied the formation and modification of the nonproteinogenic amino acid enduracididine (End), which exists in two important antibiotics, mannopeptimycins (MPPs) and enduracidin. Sequence analysis of the MPP gene cluster revealed that the product of...
    Resource Type:
    Masters Thesis
    Full Text:
    approved: _______________________________________________ T. Mark Zabriskie