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Filtering by: Creator Khan, Maryam Remove constraint Creator: Khan, Maryam Subject Antineoplastic agents Remove constraint Subject: Antineoplastic agents

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  • A novel mechanism of chemoprevention by sulforaphane : inhibition of histone deacetylase

    Creator:
    Myzak, Melinda C.
    Abstract:
    Targeting the epigenome, including the use of histone deacetylase (HDAC) inhibitors, is a novel strategy for cancer chemoprevention. Sulforaphane (SFN), a compound found at high levels in broccoli and broccoli sprouts, is a potent inducer of Phase 2 detoxification enzymes and inhibits tumorigenesis in animal models. SFN also has a...
    Resource Type:
    Dissertation
    Full Text:
    - Fageeh, Philip Tong, Chris Larsen, Robert Weston, Roland Corden, Maryam Mousaoui, Gayle Orner, Valerie