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Filtering by: Creator Schumann, Canan B. Subject Antineoplastic agents

Natural products studies of the marine cyanobacteria Lyngbya semiplena and Lyngbya majuscula

Creator:

Han, Bingnan

Abstract:

This thesis details my investigations of marine cyanobacterial natural products that resulted in the discovery of eighteen new secondary metabolites. Isolation and characterization of these unique molecules were carried out using different chromatographic techniques and by careful analyses of 1D and 2D NMR data, respectively. Preliminary bioassays of the crude...

Resource Type:

Dissertation

Full Text:

and B were approximately 10-fold more toxic than C and 0 to these cell lines. Lyngbya majuscula has
Mandelalides as Potent Mitochondrial ATP Synthase Inhibitors : From Discovery of New Analogs to Function-Oriented Synthetic Studies

Creator:

Nazari, Mohamad

Abstract:

Our quest for pharmaceutically important marine natural products led to re-isolation of known mandelalides A-D and identification of new congeners E-L from re-collected South African Lissoclinum tunicate specimens. Mandelalides A, B, and L were characterized as selective cancer cell toxins, with an unusual activity profile influenced by their glycosylation /...

Resource Type:

Dissertation

Full Text:

Lissoclinum tunicate specimens. Mandelalides A, B, and L were characterized as selective cancer cell toxins