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Filtering by: Creator Ding, Jun Subject Antioxidants -- Physiological effect

Control of p53 tumor suppressor and peroxiredoxin activity through shifts incellular redox balance

Creator:

Stoner, Christopher S.

Abstract:

Aerobic organisms have evolved many sensory mechanisms that allow response to oxidants in the environment. One area of interest is the relationship between the activity of the tumor suppressor protein p53 and the redox state of thioredoxin. Human p53 activity is severely compromised in budding yeast lacking thioredoxin reductase. Evidence...

Resource Type:

Dissertation

Full Text:

conditions [Ding et al., 1996]. Transcriptional activity of SoxR is only apparent once iron-sulfur centers
Underlying Mechanisms of the Anti-inflammatory and Antioxidant Effects of Quercetin in Human Aortic Endothelial Cells : Implications for Vascular Inflammation and Atherosclerosis

Creator:

Li, Chuan

Abstract:

Atherosclerosis is the underlying cause of ischemic heart disease and stroke and is the leading cause of death worldwide, especially in developed countries. As an inflammatory disease of arteries in a hyperlipidemic milieu, expression of adhesion molecules, such as endothelial-leukocyte adhesion molecule-1 (E-selectin) and intercellular adhesion molecule-1 (ICAM-1), on endothelial...

Resource Type:

Dissertation

Full Text:

protein kinase C (PKC) [Patel 2008][ Huang 2002] [Bloom 2003], c-Jun N-terminal kinase (JNK), p38 MAP