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Filtering by: Creator Filichkin, Sergei A. Remove constraint Creator: Filichkin, Sergei A. Subject Bioinformatics Remove constraint Subject: Bioinformatics

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  • Computational Approaches for Understanding Combinatorial Gene Regulation

    Creator:
    Ansariola, Mitra
    Abstract:
    Gene regulation is a complex mechanism that controls the spatial and temporal expression of genes in a living cell. My dissertation studies focus on two problems. First, tissue-specific gene expression prediction from DNA sequence and chromatin state, and second, the accurate discovery of small over-represented regulatory circuits in gene regulatory...
    Resource Type:
    Dissertation
    Full Text:
    Dr. Je↵ Chang, Dr. Barbara Taylor, Dr. Sergei Filichkin, and Dr. Maria Ivanchenko. I also would

  • Prediction of gene transcription start sites and initiation patterns from DNA sequence content

    Creator:
    Morton, Taj H.
    Abstract:
    The computational identification of gene Transcription Start Sites (TSSs) can provide insights into the regulation and function of genes without performing expensive experiments, particularly in organisms with incomplete annotations. High-resolution general-purpose TSS prediction remains a challenging problem, with little recent progress on the identification and differentiation of TSSs which are...
    Resource Type:
    Masters Thesis
    Full Text:
    , Jason Cumbie, Sergei Filichkin, Maria Ivanchenko, and Spencer Kisler—for all their advice and

  • Algorithms for massive biological datasets

    Creator:
    Bryant, Douglas W. (Douglas Wesley)
    Abstract:
    Within the past several years the technology of high-throughput sequencing has transformed the study of biology by offering unprecedented access to life's fundamental building block, DNA. With this transformation's potential a host of brand-new challenges have emerged, many of which lend themselves to being solved through computational methods. From de...
    Resource Type:
    Dissertation
    Full Text:
    transformation’s potential a host of brand-new challenges have emerged, many of which lend themselves to being