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Filtering by: Creator Svensson, A. Remove constraint Creator: Svensson, A. Subject Biosensors Remove constraint Subject: Biosensors

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  • A network approach for the mechanistic classification of bioactive compounds

    Creator:
    Siebert, Trina A.
    Abstract:
    Using network architecture to describe a biological system is an effective organizational method. The utility of this approach, which generally applies to qualitative models, is enhanced by the addition of quantitative models characterizing the interactions between network nodes. A chromatophore-based signal transduction network is developed, and the highly interconnected major...
    Resource Type:
    Dissertation
    Full Text:
    AN ABSTRACT OF THE DISSERTATION OF Trina A. Siebert for the

  • Biologically inspired biosensors from fish chromatophores

    Creator:
    Young, Jun
    Abstract:
    This thesis explores the feasibility of using melanophore-based biosensors from Oreochromis niloticus. Melanophores are one type of pigmented cell of the scales and fins of fish that respond in a motile fashion to a diverse range of stimuli. Fish scales were employed as the first step in determining the utility...
    Resource Type:
    Masters Thesis
    Full Text:
    and fins of fish that respond in a motile fashion to a diverse range of stimuli. Fish scales were

  • Incorporation of chromatophores into multi-cellular biosensors

    Creator:
    Preston, R. Ryan
    Abstract:
    Methodologies that detect biologically active substances have important potential applications for medical diagnostics, drug discovery, and chemical and biological anti-terrorism efforts. The wide spectrum of potential analytes that induce a physiological response dictates that novel techniques be developed to more rapidly screen and characterize agents that are more economical and...
    Resource Type:
    Dissertation
    Full Text:
    odorants that affect cellular cAMP levels (Lerner et al. 1988); (Lundstrom and Svensson 1998). In a

  • Analysis of Betta splendens erythrophore responses to Bacillus cereus cultured in different media

    Creator:
    Austin, Melissa J.
    Abstract:
    Biological agents and their products commonly cause foodborne illnesses. In the United States it is estimated that there are over 76 million cases of foodborne illnesses each year, resulting in an economic loss of approximately $40 billion. These high figures demonstrate the need for bioassays that display a rapid and...
    Resource Type:
    Masters Thesis
    Full Text:
    a rapid and accurate response to biologically active agents such as the products produced by

  • Bacterial pathogens and associated toxins involved in erythrophore cell aggregation

    Creator:
    Hutchison, Janine R.
    Abstract:
    Current detection methods for bacterial contamination rely on structure based detection of proteins and nucleic acids. While these methods are easy to use and reliable, they cannot evaluate the toxicity of a sample and the potential to cause disease. Previously, erythrophore cells derived from Betta splendens had been suggested as...
    Resource Type:
    Dissertation
    Full Text:
    reliable, they cannot evaluate the toxicity of a sample and the potential to cause disease. Previously

  • Chromatophores as cell-based biosensors for the detection of chemically and biologically toxic substances

    Creator:
    Dukovcic, Stephanie R.
    Abstract:
    Cell-based biosensors are function-based detectors that use the physiological response of a living cell to sense biologically stimulating agents. This emerging technology extends the application of current detection methods by reporting on the toxicity of a sample and the potential to cause disease. Previously, Betta splendens erythrophores have been described...
    Resource Type:
    Dissertation
    Full Text:
    response of a living cell to sense biologically stimulating agents. This emerging technology extends the