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Filtering by: Creator Pereira, Alexandre Costa Subject Cancer -- Immunological aspects Subject Indole -- Physiological effect

Chronic exposure of rodents to indole-3-carbinol and 3,3'-diindolylmethane : implications for drug metabolism, chemoprevention and human health

Creator:

Leibelt, Dustin A.

Abstract:

Indole-3-carbinol (I3C) is a naturally occurring plant alkaloid, found in significant concentrations in cruciferous vegetables such as broccoli and Brussels sprouts. I3C is an unstable compound that undergoes rapid oligomerization in an acidic environment to form higher order condensation products (I3C-ACPs), such as 3-3'-diindolylmethane (DIM). Both I3C and DIM are...

Resource Type:

Dissertation

Full Text:

Pereira, Kathi Georgitis and Greg Jenkins were responsible for statistical analysis of data for all
Application of toxicogenomics to determine mechanism of tumor modulation by dietary indole phytochemicals in hepatocellular carcinoma

Creator:

Tilton, Susan C.

Abstract:

Indole-3-carbinol (I3C) and 3,3'-diindolylmethane (DIM), a primary I3C derivative in vivo, are known chemopreventive agents available as dietary supplements. I3C was found to suppress or enhance tumors in several animal models. Chemoprotection is attributed to the ability of indoles to alter carcinogen metabolism effectively blocking initiation. However, mechanisms for enhancement...

Resource Type:

Dissertation

Full Text:

Research Laboratory. I also thank Dr. Cliff Pereira for his advice and statistical support on these