Blastocystis spp. is a common intestinal parasite in humans and animals that has been associated with acute or chronic digestive disorders such as irritable bowel syndrome. Serotonin mediates intestinal motility, sensation, and secretory function in the normal intestinal tract. Serotonin (5-HT) signaling is decreased in animal models of colitis, as...
In addition to the well-characterized genomic mechanism of steroid action that uses
intracellular receptors, steroid hormones also signal through nongenomic processes
that use membrane receptors. A membrane receptor for corticosterone (CORT) has
been described in brains of the roughskin newt (Taricha granulosa). This receptor is
believed to be a G-protein...
Studies using the pluripotent embryonic carcinoma cell line, P19, as a retinoic acid (RA)-responsive model system have been instrumental towards our understanding of the RA-dependent signaling pathways in development and homeostasis. Grp1-associated scaffold protein (GRASP; also known as Tamalin) was first identified by our group, as a gene robustly induced...