The hepatotoxicity of CB was studied in the Sprague-Dawley rat and rainbow trout. In rats, an ip dosage of 9.8 mmol/kg CB (~̲ LD10) produced evidence of liver toxicity over a 72 hr time course. Sulfobromophthalein (BSP) retention maximized 3-16 hr post treatment and normalized after 72 hr whereas plasma...
Several experiments were undertaken to investigate the mechanism of
photodechlorination of pentachlorobenzene. The thermal methoxydechlorination
reaction of pentachlorobenzene was studied. In DMSO at 50 °C sodium
methoxide reacts smoothly with pentachlorobenzene to give three
tetrachloroanisole isomers. A second-order kinetic plot for this reaction is linear to
high precision, indicating that...