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Filtering by: Creator Terwilliger, Mark Subject Crystallography

Modeling protein structure at atomic resolution

Creator:

Berkholz, Donald S.

Abstract:

This thesis includes three studies involving different aspects of modeling protein structure. The first study illustrates the levels of insight available from atomic-resolution protein structures. The second study derives general trends of protein geometry from atomic-resolution structures and shows their implications for modeling. The third study creates a model of...

Resource Type:

Dissertation
Model systems for structural investigations into peroxiredoxin catalysis, conformation change, and inactivation

Creator:

Perkins, Arden

Abstract:

Peroxiredoxin (Prx) enzymes catalyze the reduction of hydrogen peroxide, peroxynitrous acid, and organic peroxides, and are extremely efficient peroxidases, with k[subscript cat]/K[subscript M] on the order of 10⁷ - 10⁸ M⁻¹ s⁻¹. Besides their role in oxidative stress defense, evidence has accumulated that some eukaryotes, including humans, use Prxs as...

Resource Type:

Dissertation