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Filtering by: Creator Chen, Chengci, 1964- Remove constraint Creator: Chen, Chengci, 1964- Subject DNA -- Structure Remove constraint Subject: DNA -- Structure

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  • Analyses of noncanonical DNA structures

    Creator:
    Khuu, Patricia A.
    Abstract:
    The structural polymorphic nature of DNA has been long been recognized since the model of the right-handed B-DNA duplex proposed by James Watson and Francis Crick was accepted. Its malleability is thought to be critical in protein recognition and manipulation. In particular, it can form Holliday junctions, four-way DNA structural...
    Resource Type:
    Dissertation
    Full Text:
    four-way DNA junction was first proposed by Robin Holliday in 1964 as the central structural

  • Sequence dependent conformational variations in DNA holliday junctions

    Creator:
    Hays, Franklin A.
    Abstract:
    Four-stranded DNA junctions (also known as Holliday junctions) are structural intermediates involved in a growing number of biological processes including DNA repair, genetic recombination, and viral integration. Although previous studies have focused on understanding the conformational variability and sequence-dependent formation of Holliday junctions in solution there have been relatively few...
    Resource Type:
    Dissertation
    Full Text:
    Introduction Four-stranded DNA junctions were first proposed by Robin Holliday in 1964 to explain abnormal

  • The effect of cytosine methylation on DNA structure

    Creator:
    Vargason, Jeffrey M.
    Abstract:
    DNA methylation is common in prokaryotes and eukaryotes and has been implicated in various biological roles including gene silencing, X-chromosome inactivation, and genomic imprinting. 5-methylcytosine the "fifth base" of the genetic code comprises 1-3% of the human genome and is primarily found on cytosines within the context of the CpG...
    Resource Type:
    Dissertation

  • The analysis and prediction of DNA structure

    Creator:
    Basham, Beth E.
    Abstract:
    As genome sequencing projects begin to come to completion, the challenge becomes one of determining how to understand the information contained within the DNA. DNA is a polymorphic macromolecule; the A- B- and Z-DNA conformations have been observed by a variety of physical techniques. The magnitude of the energetic differences...
    Resource Type:
    Dissertation
    Full Text:
    between the structure and hydration for DNA conformations (Brahms and Mommaetrs, 1964; Ivanov et al

  • Base inclinations for DNA in solutions and films as revealed by linear dichroism

    Creator:
    Kang, Hunseung
    Resource Type:
    Dissertation
    Full Text:
    external electric fields (Chen & Clark, 1969, 1973; Hug & Tinoco, 1973; Clark, 1977, 1986, 1989, 1990