Index Catalog // ScholarsArchive@OSU

Nucleoside diphosphokinase of Escherichia coli and its interactions with bacteriophage T4 proteins of DNA synthesis

Creator:: Ray, Nancy Bisset
Resource Type:: Dissertation
Full Text:: for the degree of Doctor of Philosophy in Biochemistry and Biophysics presented on May 8, 1992 Title

Vaccinia virus ribonucleotide reductase : gene sequencing, intracellular localization, and interaction with a DNA-binding protein

Creator:: Davis, Ralph Eugene, 1957-
Abstract:: Vaccinia virus infected monkey kidney cells had been previously shown to have an increased ribonucleoside diphosphate reductase (RR) activity. DNA from mutant virus resistant to hydroxyurea were digested with restriction endonucleases and were shown to have substoichiometric amounts of the Hind III F fragment. Additional information from Southern blotting experiments...
Resource Type:: Dissertation
Full Text:: THESIS OF Ralph Eugene Davis for the degree of _Qoctor of Philosophy in Biochemistry and Biophysics

Insights into mammalian DNA replication from analysis of mutations affecting deoxyribonucleotide biosynthesis

Creator:: Mun, Byung-joo
Abstract:: Although the synthesis of DNA precursors is closely coordinated with DNA replication, it is still not clear whether deoxyribonucleoside triphosphates (dNTPs) influence DNA replication independently of their interactions with DNA polymerase catalytic sites. In an effort to understand the extent to which rate and fidelity of DNA replication are regulated...
Resource Type:: Dissertation
Full Text:: degree of Doctor of Philosophy in Biochemistry and Biophysics presented on May 3, 1990. Title: Insights

Mutagenic mechanisms associated with perturbations of DNA precursor biosynthesis in phage T4

Creator:: Ji, Jiuping
Abstract:: A crucial factor in determining the accuracy of DNA replication is maintenance of a balanced supply of deoxyribonucleoside triphosphates (dNTPs) at replication forks. Perturbation of dNTP biosynthesis can induce dNTP pool imbalance with deleterious genetic consequences, including increased mutagenesis, recombination, chromosomal abnormalities and cell death. Using the T4 bacteriophage system,...
Resource Type:: Dissertation
Full Text:: Philosophy in Genetics presented on November 2. 1990 Title: Mutagenic Mechanisms Associated with

Modulation of deoxyribonucleoside triphosphate levels, DNA synthesis rates and fidelity in mammalian cells

Creator:: Martomo, Stella A.
Abstract:: Deoxyribonucleoside triphosphate (dNTP) concentrations measured in cells are not symmetric. dGTP almost always represents only 5-10% of the total dNTP pools in cells. In an in vitro replication system involving semiconservative replication from an SV 40 origin, the mutation frequency of an M13 phagemid replicated by human cell extracts in...
Resource Type:: Dissertation
Full Text:: of Doctor of Philosophy in Biochemistry and Biophysics presented on April 9, 2002. Title

Protein-protein interactions in the bacteriophage T4-coded dCTPase-dUTPase

Creator:: Ungermann, Christian
Resource Type:: Masters Thesis
Full Text:: , virology, and molecular biology have originated from research on the bacteriophage T4. The bacteriophage

Deoxyribonucleotides as determinants of DNA replication fidelity in bacteriophage T4

Creator:: Sargent, Roy Geoffrey
Abstract:: Imbalanced deoxyribonucleoside triphosphate (dNTP) pools are mutagenic for DNA synthesis in both intact cells and cell-free replication systems. Almost certainly, such mutagenesis involves competition between correctly and incorrectly base-paired precursors at replication sites. However, there are certain differences between the intact cell and cell-free systems that do not always allow...
Resource Type:: Dissertation
Full Text:: of Philosophy in Biochemistry and Biophysics presented on March 20, 1987 . Title

Character of the DNA region encoding a portion of the DNA-dependent RNA polymerase in Bacillus subtilis

Creator:: Jones, Margaret Carol Jackson
Resource Type:: Dissertation
Full Text:: for the degree of Doctor of Philosophy (Name) in Microbiology presented on March 21, 1975 (Major

DNA precursor compartmentation in mammalian cells : distribution and rates of equilibration between nucleus and cytoplasm

Creator:: Leeds, Janet M.
Abstract:: A rapid nuclear isolation technique was adapted in order to examine the question of DNA precursor compartmentation in mammalian cells. By using this method a reproducible proportion of the cellular nucleotides remained associated with the isolated nuclei. Examination, at several different cell densities, of exponentially growing HeLa cells showed that...
Resource Type:: Dissertation
Full Text:: . Leeds, for the degree of Doctor of Philosophy in Biochemistry and Biophysics, presented on March 21

Attempted cloning of T4 phage ribonucleotide reductase

Creator:: Booth, Joseph
Abstract:: Ribonucleotide reductase is an important enzyme in the control of DNA replication within the cell. Ribonucleotide reductase exerts its control through enzymatic reduction of nucleoside diphosphates. The bacteriophage T4 enzyme is an example of the class of iron-requiring reductases which also includes E. coli and mammalian ribonucleotide reductases. The two...
Resource Type:: Masters Thesis

Deoxyribose-phosphate aldolase and the biosyntheiss of DNA in the chick embryo

Creator:: Anderson, Martin Michael
Abstract:: The activity of deoxyribose-phosphate aldolase was determined in chick embryo brains, hearts and livers during the course of development. Assays were made in the direction of synthesis of deoxyribose-5-phosphate. Low levels of activity in the brain and heart remained constant throughout the course of development. Activity in the liver expressed...
Resource Type:: Dissertation
Full Text:: Doctor of Philosophy (Name of student) (Degree) in Biochemistry (Major) presented on 1 April 1970 (Date

Semiconductor Nanocrystals as Detection Components in Microfluidic Analytical Systems

Creator:: Pengpumkiat, Sumate
Abstract:: Miniaturized and portable microfluidic analytical platforms have been widely explored in the broad field of chemical analysis. The concept of microfluidics offer a number of important advantages, including low reagent consumption, low-cost detection, high sample throughput, and shorter analysis time. Semiconductor nanocrystals or quantum dots have been extensively utilized in...
Resource Type:: Dissertation
Full Text:: Pengpumkiat for the degree of Doctor of Philosophy in Chemistry presented on March 17, 2017. Title

Enzyme associations in deoxyribonucleotide biosynthesis : anti-idiotypic antibodies as probes for direct protein-protein interactions

Creator:: Young, James Patrick
Abstract:: The ability to faithfully replicate DNA is dependent upon the maintenance and regulation of its precursors, the deoxyribonucleoside triphosphates. Enzymes encoded by the bacteriophage T4 have been widely used as models of biochemical processes. A body of evidence supports the concept that the bacteriophage T4 enzymes involved in deoxyribonucleotide biosynthesis...
Resource Type:: Dissertation
Full Text:: OF James Patrick Younq for the degree of Doctor of Philosophy in Biochemistry and Biophysics

Organization of T4 bacteriophage genes and gene products involved in DNA precursor biosynthesis

Creator:: Wang, Yeong
Abstract:: Bacteriophage T4 gene 42 encodes dCMP hydroxymethylase, an enzyme unique to the deoxyribonucleotide metabolism of T-even bacteriophages. To study biochemical and biophysical properties of the enzyme, as well as the interaction of dCMP hydroxymethylase with other DNA precursor biosynthetic enzymes in vitro, availability of large amounts of the enzyme is...
Resource Type:: Dissertation
Full Text:: of Philosophy in Biochemistry and Biophysics presented on May 5. 1989. Title: Organization of T4

Studies on DNA precursor metabolism in vaccinia virus-infected mamalian cells

Creator:: Spiro, Craig
Abstract:: Vaccinia virus-infected animal cells have been used to study the interactions between the replication of deoxyribonucleic acid (DNA) and the biosynthesis of its nucleotide precursors. Some antimetabolites that inhibit DNA replication have as their targets enzymes of nucleotide biosynthesis. Furthermore, the disruption of nucleotide metabolism can alter the fidelity of...
Resource Type:: Dissertation
Full Text:: -infected mamalian cells AN ABSTRACT OF THE THESIS OF Craig Spiro for the degree of Doctor of Philosophy

Sequence conversion during adenovirus DNA replication

Creator:: Bennett, Kelly L.
Abstract:: The work in this thesis has provided conclusive genetic evidence that "panhandle" intermediates form during adenovirus replication. Adenovirus chromosomes lacking 51 by from their left -hand termini are infectious and capable of regenerating the missing origin sequence. Yet if an entire inverted terminal repeat is removed, the adenovirus chromosome is...
Resource Type:: Dissertation
Full Text:: ABSTRACT OF THE THESIS OF Kelly L. Bennett for the degree of Doctor of Philosophy in Biochemistry and

ScholarsArchive@OSU

Nucleoside diphosphokinase of Escherichia coli and its interactions with bacteriophage T4 proteins of DNA synthesis

Vaccinia virus ribonucleotide reductase : gene sequencing, intracellular localization, and interaction with a DNA-binding protein

Insights into mammalian DNA replication from analysis of mutations affecting deoxyribonucleotide biosynthesis

Mutagenic mechanisms associated with perturbations of DNA precursor biosynthesis in phage T4

Modulation of deoxyribonucleoside triphosphate levels, DNA synthesis rates and fidelity in mammalian cells

Protein-protein interactions in the bacteriophage T4-coded dCTPase-dUTPase

Deoxyribonucleotides as determinants of DNA replication fidelity in bacteriophage T4

Character of the DNA region encoding a portion of the DNA-dependent RNA polymerase in Bacillus subtilis

DNA precursor compartmentation in mammalian cells : distribution and rates of equilibration between nucleus and cytoplasm

Attempted cloning of T4 phage ribonucleotide reductase

Deoxyribose-phosphate aldolase and the biosyntheiss of DNA in the chick embryo

Semiconductor Nanocrystals as Detection Components in Microfluidic Analytical Systems

Enzyme associations in deoxyribonucleotide biosynthesis : anti-idiotypic antibodies as probes for direct protein-protein interactions

Organization of T4 bacteriophage genes and gene products involved in DNA precursor biosynthesis

Studies on DNA precursor metabolism in vaccinia virus-infected mamalian cells

Sequence conversion during adenovirus DNA replication

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