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Filtering by: Creator Nandpuri, Karam Singh Subject DNA -- Synthesis

Enzyme associations in deoxyribonucleotide biosynthesis : anti-idiotypic antibodies as probes for direct protein-protein interactions

Creator:

Young, James Patrick

Abstract:

The ability to faithfully replicate DNA is dependent upon the maintenance and regulation of its precursors, the deoxyribonucleoside triphosphates. Enzymes encoded by the bacteriophage T4 have been widely used as models of biochemical processes. A body of evidence supports the concept that the bacteriophage T4 enzymes involved in deoxyribonucleotide biosynthesis...

Resource Type:

Dissertation
Protein-protein interactions in the bacteriophage T4-coded dCTPase-dUTPase

Creator:

Ungermann, Christian

Resource Type:

Masters Thesis
Organization of T4 bacteriophage genes and gene products involved in DNA precursor biosynthesis

Creator:

Wang, Yeong

Abstract:

Bacteriophage T4 gene 42 encodes dCMP hydroxymethylase, an enzyme unique to the deoxyribonucleotide metabolism of T-even bacteriophages. To study biochemical and biophysical properties of the enzyme, as well as the interaction of dCMP hydroxymethylase with other DNA precursor biosynthetic enzymes in vitro, availability of large amounts of the enzyme is...

Resource Type:

Dissertation
Mutagenic mechanisms associated with perturbations of DNA precursor biosynthesis in phage T4

Creator:

Ji, Jiuping

Abstract:

A crucial factor in determining the accuracy of DNA replication is maintenance of a balanced supply of deoxyribonucleoside triphosphates (dNTPs) at replication forks. Perturbation of dNTP biosynthesis can induce dNTP pool imbalance with deleterious genetic consequences, including increased mutagenesis, recombination, chromosomal abnormalities and cell death. Using the T4 bacteriophage system,...

Resource Type:

Dissertation
Nucleoside diphosphokinase of Escherichia coli and its interactions with bacteriophage T4 proteins of DNA synthesis

Creator:

Ray, Nancy Bisset

Resource Type:

Dissertation