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Repression of DNA Mismatch Repair (MMR) in Arabidopsis thaliana through Dominant-Negative MMR Proteins

Creator:: Mohamed, Aly
Abstract:: The highly conserved multi-protein mismatch repair (MMR) system is known for its ability to correct post replication errors in genomic DNA. A hallmark of MMR deficiency in all organisms is microsatellite instability. The initiating proteins in the eukaryotic MMR system are hetrodimers formed with an integral MSH2 subunit and one...
Resource Type:: Honors College Thesis
Full Text:: Bioresource Research, Biotechnology presented December 1, 2006. Title: Repression of DNA Mismatch Repair

DNA UV damage-related control of ribonucleotide reductase : possible relationship to mutagenesis and the incidence of and attitudes toward skin cancer in several western nations

Creator:: Stenberg, John C.
Abstract:: Two strains of Escherichia coli were studied to determine the effect of constitutive expression of the SOS DNA damage repair response on the activity of ribonucleotide reductase. Activity of the reductase and cellular deoxynucleoside triphosphate (dNTP) pools were both determined before and after exposure of the cells to ultraviolet radiation....
Resource Type:: Honors College Thesis
Full Text:: to laboratory research, the topic of skin cancer in the Western world was also examined. Data from

Effects of DNA mismatch repair inhibition in Arabidopsis thaliana

Creator:: Wilcox, Buck W. L.
Abstract:: Genomic instability underlies diseases of unregulated cell growth that result in cancers and developmental abnormalities in humans. Similar genome destabilizing mechanisms are used to create genetic variety in crops for use in breeding and trait development. Errors that occur during DNA replication may cause mutations if they are not corrected...
Resource Type:: Dissertation
Full Text:: tools maintained in the Center for Genome Research and Bioinformatics at Oregon State University. I

Mismatch repair in plants : identification and characterization of Arabidopsis thaliana MutS homolog proteins

Creator:: Culligan, Kevin M.
Resource Type:: Dissertation
Full Text:: from Arabidopsis thaliana cDNA libraries. Utilizing Arabidopsis thaliana genome sequences deposited

Hypermutagenic induction of mitotic recombination by ionizing radiation in Mlhl null mouse cells

Creator:: Wang, Qi
Abstract:: Mitotic recombination is a common autosomal mutation in mammalian cells involving crossover events between homologous chromosomes. This process can convert a cell with a heterozygous deficiency to one with a homozygous deficiency, and thus often represents the second step in tumor suppressor gene inactivation. In this study I examined the...
Resource Type:: Masters Thesis
Full Text:: suggestions that helped to shape my research and life career goals. His valuable feedback contributed

Functional analysis of the pathogenic mutation MLH1-E578G on human MLH1 activity in DNA mismatch repair

Creator:: Huo, Xin
Abstract:: Mismatch repair (MMR) system performs mainly three roles to maintain genomic stability, correct DNA biosynthetic errors, ensure the fidelity of genetic recombination, and in mammalian cells participate in the cellular response to some DNA damages. Deficiencies in mismatch repair increase mutation rates and cancer risks. In eukaryotes, the MMR system...
Resource Type:: Masters Thesis
Full Text:: questions regarding research. He gave me invaluable feedbacks when needed and supported me with different

DNA mismatch repair-dependent responses to the food-borne carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the mouse

Creator:: Smith-Roe, Stephanie L.
Abstract:: The DNA mismatch repair (MMR) pathway maintains genomic stability and reduces cancer risk (colorectal and other internal cancers) by correcting polymerase errors and activating cell cycle checkpoints and apoptosis in response to DNA damage. Few studies have examined the influence of commonly encountered environmental mutagens/carcinogens on the etiology of MMR-deficient...
Resource Type:: Dissertation
Full Text:: research design, and interpreting and communicating research results. I thank him for his kindness

An assay for screening cells for mismatch repair proficiency in vivo

Creator:: Wu, Shiau-Yin
Abstract:: Mismatch repair is one of the mechanisms by which cells ensure genomic stability. Deficiencies in mismatch repair (MMR) increase mutation rates and cancer risks. In the well-characterized methyl-directed Escherichia co/i system, MMR is initiated by MutS, Mut L, and MutH proteins. The single MutS protein and the single MutL protein...
Resource Type:: Masters Thesis
Full Text:: of simple repetitive microsatellite sequences that occur throughout the genome. MSI likely results

Spontaneous and enviornmental [sic] mutagenesis in mismatch repair deficient cells

Creator:: Shin-Darlak, Chi Y.
Abstract:: DNA damage, if not repaired, can become a mutation. Mutation accumulation is associated with initiation and progression of tumorigenesis. DNA mismatch repair (MMR) is required for maintaining genetic stability by repairing replication errors. Biochemical studies have shown that MMR also recognizes mismatch-causing DNA lesions, suggesting the role of MMR in...
Resource Type:: Dissertation
Full Text:: throughout the genome. The mechanism for the CIN phenotype involves inactivation of genes required for

Isolation and characterization of DNA-damage-repair/toleration genes from Arabidopsis thaliana

Creator:: Pang, Qishen
Resource Type:: Dissertation
Full Text:: irradiation. Research results indicated the following: (1) UV (254 nm) fluences that result in measurable

ScholarsArchive@OSU

Repression of DNA Mismatch Repair (MMR) in Arabidopsis thaliana through Dominant-Negative MMR Proteins

DNA UV damage-related control of ribonucleotide reductase : possible relationship to mutagenesis and the incidence of and attitudes toward skin cancer in several western nations

Effects of DNA mismatch repair inhibition in Arabidopsis thaliana

Mismatch repair in plants : identification and characterization of Arabidopsis thaliana MutS homolog proteins

Hypermutagenic induction of mitotic recombination by ionizing radiation in Mlhl null mouse cells

Functional analysis of the pathogenic mutation MLH1-E578G on human MLH1 activity in DNA mismatch repair

DNA mismatch repair-dependent responses to the food-borne carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the mouse

An assay for screening cells for mismatch repair proficiency in vivo

Spontaneous and enviornmental [sic] mutagenesis in mismatch repair deficient cells

Isolation and characterization of DNA-damage-repair/toleration genes from Arabidopsis thaliana

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