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Filtering by: Creator Sung, Chih-Jen Subject DNA repair

Characterization of Escherichia coli double-strand uracil-DNA glycosylase and analysis of uracil-initiated base excision DNA repair

Creator:

Sung, Jung-Suk

Abstract:

Escherichia coli double-strand uracil-DNA glycosylase (Dug) was purified to apparent homogeneity from bacteria that were defective in uracil-DNA glycosylase (Ung). After cloning the dug gene, recombinant Dug was overexpressed, purified, and characterized with respect to activity, substrate specificity, product DNA binding, and mechanism of action. Purified Dug excised both uracil...

Resource Type:

Dissertation

Full Text:

AN ABSTRACT OF THE THESIS OF Tung-Suk Sung for the degree of
Spontaneous and enviornmental [sic] mutagenesis in mismatch repair deficient cells

Creator:

Shin-Darlak, Chi Y.

Abstract:

DNA damage, if not repaired, can become a mutation. Mutation accumulation is associated with initiation and progression of tumorigenesis. DNA mismatch repair (MMR) is required for maintaining genetic stability by repairing replication errors. Biochemical studies have shown that MMR also recognizes mismatch-causing DNA lesions, suggesting the role of MMR in...

Resource Type:

Dissertation
Mismatch repair in plants : identification and characterization of Arabidopsis thaliana MutS homolog proteins

Creator:

Culligan, Kevin M.

Resource Type:

Dissertation