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Filtering by: Subject DNA-binding proteins

DNA binding and beyond : an investigation of proteins involved in PAH-induced carcinogesesis

Creator:

Hooven, Louisa Ada

Abstract:

Exposure to polycyclic aromatic hydrocarbons such as benzo[a]pyrene (B[a]P) has been determined to be a risk factor for various forms of human cancer. PAH DNA adducts have been shown to cause mutations, but carcinogenesis is also accompanied by alterations in gene expression. Inhibiting individual cytochrome P450s could clarify the interaction...

Resource Type:

Dissertation
Organization of the T4 dNTP synthetase complex at DNA replication sites

Creator:

Kim, JuHyun

Abstract:

With respect to a multienzyme complex of deoxyribonucleoside triphosphate (dNTP) synthesis somehow juxtaposed with DNA replication sites, our laboratory has demonstrated the existence of a multienzyme complex in T4-infected E. coli, named the T4 dNTP synthetase complex, but the idea of direct linkage of dNTP synthesis to DNA replication and...

Resource Type:

Dissertation
Transcriptional repression by CTIP2, a C2H2 zinc finger protein

Creator:

Topark-Ngarm, Acharawan Khamsiritrakul

Abstract:

CTIP2, a novel C2H2 zinc finger protein, is a transcriptional repressor that functions by at least two mechanisms. CTIP2 interacts with and stimulates transcriptional repression mediated by COUP-TF family members. CTIP2 also represses transcription independently of COUP-TF proteins by direct, sequence-specific DNA binding activity. CTIP2 has been implicated in lymphoid...

Resource Type:

Dissertation