Index Catalog // ScholarsArchive@OSU

Start Over

Filtering by: Creator Kuriyama, Y. Subject Dendritic cells

Direct effects of 2,3,7,8 tetrachlorodibenzo-p-dioxin on antigen-presenting cells and molecular signaling pathways in dendritic cells

Creator:

Ruby, Carl E.

Abstract:

In experimentally exposed mice, the environmental contaminant 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) produces significant suppression of adaptive immune responses at low doses. However, the underlying biochemical and cellular mechanisms of TCDD-induced immunotoxicity have remained elusive since the identification of these effects nearly 30 years ago. Antigen-presenting cells (APC) constitute various populations of...

Resource Type:

Dissertation
Investigations into the mechanism of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced immune suppression: effects on dendritic cell phenotype and function

Creator:

Vorderstrasse, Beth A.

Abstract:

T cell-dependent immune responses are highly sensitive to suppression by exposure to the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), yet direct effects of TCDD on T cells have been difficult to demonstrate. Because the activation of naive T cells is initiated by dendritic cells (DC), the studies presented in this dissertation were...

Resource Type:

Dissertation

Full Text:

Privacy cells and the production of IL-2, IL-4, and IFN-y was not suppressed but instead tended to be