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Filtering by: Creator O'Dea, Annika Subject Developmental toxicology

Defining PAH and Oxygen-substituted PAH-dependent Developmental and Adult Toxicity in Zebrafish

Creator:

Knecht, Andrea L.

Abstract:

Polycyclic aromatic hydrocarbons (PAHs) and oxygen-substituted PAHs (OPAHs) are environmental contaminants present in urban air, dust, soil and water resulting from incomplete combustion of organic materials or fossil fuels; found in crude oil and coal; and formed through photoxidation or biotransformation of microbial. It is widely recognized that PAHs pose...

Resource Type:

Dissertation

Full Text:

research community. • In Chapter 2, Dr. Britton Goodale conducted AHR morpholino knockdown, Annika
Developmental toxicity of polycyclic aromatic hydrocarbons : defining mechanisms with systems-based transcriptional profiling

Creator:

Goodale, Britton C.

Abstract:

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in the environment as components of fossil fuels and by-products of combustion. Defining toxicity mechanisms for this large family of multi-ring structures and substituted derivatives is a substantial challenge. Several PAHs, such as benzo(a)pyrene (BaP), are mutagenic, toxic to wildlife, and classified as probable...

Resource Type:

Dissertation

Full Text:

training in the lab, and for their mentorship and friendship; Andrea Knecht, Mike Simonich, and Annika