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Filtering by: Committee Member Hibbs%2C David E. Subject Dieldrin -- Toxicology

Dieldrin pretreatment does not induce hepatic microsomal and cytosolic epoxide hydrolase activities in rainbow trout (Oncorhyncus mykiss)

Creator:

Rosemond, Marie Victoire M.

Abstract:

Previous studies have shown that rainbow trout exposed to dieldrin via diet for 9 to 12 weeks increased biliary excretion of a subsequent dose of [¹⁴C]dieldrin by 500%. This was not explained by induction of the cytochrome P-450 (CYP) system involved in oxidative metabolism of these compounds. We hypothesized that...

Resource Type:

Masters Thesis

Full Text:

appreciation to the members of my graduate committee for their input and participation: Dr. David E. Williams
Dieldrin stimulates biliary excretion of [14 C] benzo[a]pyrene polar metabolites but does not change the metabolite profile in rainbow trout (Oncorhyncus mykiss)

Creator:

Barnhill, Melanie L.

Abstract:

Feeding rainbow trout 0.3-0.4 mg dieldrinlkg/d for 9-12 weeks stimulated the biliary excretion of a subsequent dose of [¹⁴C]dieldrin by 500% and [³H]7,12- dimethylbenz[a]anthracene (DMBA) by 240%. In vitro work demonstrated that this interaction occurred without induction of the cytochrome P450 system, or other hepatocellular proteins involved in metabolism. The...

Resource Type:

Masters Thesis

Full Text:

the members of my graduate committee for their input and participation: Dr. David E. Williams, Dr