Index Catalog // ScholarsArchive@OSU

Start Over

Filtering by: Creator Jayaraman, A. Subject Escherichia coli

Accessibility of highly conserved RNA sequences of Escherichia coli 70S ribosomes and implications for developing antibacterial agents

Creator:

Rahman, Mohammad A.

Abstract:

Escherichia coli 16S-like ribosomal RNAs from eubacterial, archaebacterial and eukaryotic organisms have several universally conserved sequence zones which are proposed to be single-stranded. A clear function for all of these regions has not yet been defined. To evaluate the roles of these sequence zones in protein synthesis, knowledge of their...

Resource Type:

Dissertation

Full Text:

THESIS OF Mohammad A. Rahman for the degree of Doctor of Philosophy in Biochemistry and Biophysics
Oligoribonucleotides directed at ribosomal protein binding sites as inhibitors of ribosomal small subunit assembly and as possible antibiotics

Creator:

Thompson, Cynthia Sue

Abstract:

The effects of oligoribonucleotides of identical or similar sequences to a ribosomal protein binding site, specifically S8, on prokaryotic 30S ribosomal assembly were investigated in Escherichia coli. The oligoribonucleotides were expected to bind to the target protein S8 and block its incorporation into the 30S subunit, resulting in a nonfunctional...

Resource Type:

Dissertation

Full Text:

to a ribosomal protein binding site, specifically S8, on prokaryotic 30S ribosomal assembly were