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Filtering by: Creator Chung, Chuen-shang Subject Gene expression

The effect of dietary compounds on human cathelicidin antimicrobial peptide gene expression mediated through farnesoid X receptor and its potential role in gastrointestinal health

Creator:

Campbell, Yan

Abstract:

The human cathelicidin antimicrobial peptide (CAMP) is a broad spectrum microbicidal agent and modulator of both the innate and adaptive immune system. It is induced by 1,25-dihydroxyvitamin D (1,25(OH)₂D₃) through activation of the vitamin D receptor (VDR) and primary bile salts through activation of the xenobiotic nuclear receptor farnesoid X...

Resource Type:

Dissertation
Toxicogenomic Biomarkers Associated with PAH Carcinogenic Potential in a 3D in Vitro Bronchial Epithelial Model

Creator:

Chang, Yvonne

Abstract:

The environmental health science community recognizes polycyclic aromatic hydrocarbons (PAHs) as a re-emerging class of environmental pollutants due to their persistence and prominence in mixtures of concern. Due to their widespread distribution in the environment, exposure to PAHs often occur as complex chemical mixtures. Exposures are linked to numerous adverse...

Resource Type:

Dissertation