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Filtering by: Creator Gharib, Camron I. Subject Glutathione -- Physiological effect

Elevated ceramide levels contribute to the age-associated decline in vascular endothelial nitric oxide : pharmacologic administration of lipoic acid partially restores function

Creator:

Smith, Anthony R.

Abstract:

The vascular endothelium is a single cell layer that lines the lumen of the entire vasculature. It is the site of synthesis of nitric oxide (NO), a vasodilatory compound synthesized by endothelial nitric oxide synthase (eNOS). NO causes intracellular calcium sequestration of the vascular smooth muscle cells, relaxing and dilating...

Resource Type:

Dissertation

Full Text:

Chair of the Molecular and Cellular Biology Program Dean of the Graduate School I understand that my
Age-related alterations in transcriptional regulation of hepatic glutathione synthesis : remediation by R-alpha-lipoic acid

Creator:

Shenvi, Swapna V.

Abstract:

Glutathione (GSH) is the predominant low molecular weight thiol antioxidant in liver tissue. GSH plays an important role in maintaining the intracellular thiol redox ratio as well as detoxification of electrophiles and xenobiotics. Aging leads to a significant decline (35%; P ≤ 0.05) in hepatocellular GSH levels. Using young (2-4...

Resource Type:

Dissertation

Full Text:

Dean of the Graduate School I understand that my dissertation will become part of the