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Filtering by: Creator Ayuso, D. Remove constraint Creator: Ayuso, D. Subject Hydrothermal vents -- Microbiology Remove constraint Subject: Hydrothermal vents -- Microbiology

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  • Investigation of unique marine environments for microbial natural products

    Creator:
    Thornburg, Christopher C.
    Abstract:
    Metagenomics has revealed that the marine microbial biosphere is immensely more diverse than originally considered, and is an almost untapped reservoir for the potential discovery of microbial natural products. Despite numerous advances in culturing, biosynthetic engineering and genomic-based screening efforts to uncover much of this diversity in relatively accessible environments,...
    Resource Type:
    Dissertation
    Full Text:
    Sea has led to the identification of five new cyclic depsipeptides, apratoxin H, grassypeptolides D

  • Biologically active metabolites from marine microorganisms : methods to identify drug leads and chemical signals

    Creator:
    Vining, Oliver B.
    Abstract:
    Microbial natural products represent a massive repository of unique chemical scaffolds with corresponding diverse biological functions. However, in the past decade the development of natural products into new therapeutics has dwindled, in part due to the challenges posed by high rediscovery rates and low throughput associated with classical bioassay-guided fractionation...
    Resource Type:
    Dissertation
    Full Text:
    (OSU) by Dr. Andrew M. Hau, Jeffrey D. Serrill, and Dr. Justyna Sikorska. Dr. Kerry L. McPhail