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Filtering by: Advisor Proteau, Philip J. Subject Isopentenoids -- Synthesis -- Inhibitors

Syntheses and evaluation of putative enzyme inhibitor of isoprenoid biosynthesis

Creator:

Phaosiri, Chanokporn

Abstract:

The discovery of the methylerythritol phosphate pathway (the MEP pathway) as an alternate pathway for isoprenoid biosynthesis in some organisms including most bacteria, malarial parasites and plants, but not in animals, has stimulated extensive studies in this area. Research has revealed the potential of finding novel antibacterials, antimalarial drugs, and...

Resource Type:

Dissertation

Full Text:

foremost, II would like to thank my major professor, Dr. Philip Proteau for his advice, guidance, and
Studies on 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Synechocystis sp. PCC6803 : characterization of mutants and inhibitors

Creator:

Fernandes, Roberta P. M.

Abstract:

In recent years, the methyl erythritol phosphate (MEP) pathway to isoprenoids has been the subject of intensive research. The interest is because isoprenoids have important roles in many cellular processes essential for the survival of several pathogenic organisms, making the inhibition of this pathway an attractive target for the drug...

Resource Type:

Dissertation

Full Text:

Inhibitors. Abstract approved: hilip/(Proteau In recent years, the methyl erythritol phosphate (MEP