Glutathione, a ubiquitous intracellular tripeptide, protects cells by reacting with electrophiles and radicals that can damage cellular macromolecules. However, glutathione conjugation is now recognized as one mechanism by which drugs and xenobiotics can also be converted to reactive intermediates having toxic consequences to cells. The halogenated alkane 1,2-dichloroethane forms S-(2-chloroethyl)...