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Filtering by: Creator Wickramasekara, S. Subject Mass spectrometry

Mass-Spectrometric Methods for OxPTM Characterization and Quantitative Proteomics of Oxidative Stress Response

Creator:

Huang, Lin

Abstract:

Oxidative stress is deﬁned as an imbalance that favors the production of reactive oxygen species (ROS) over an organism's antioxidant defense. ROS have the ability to damage, either directly or indirectly, biomolecules including DNA, proteins, carbohydrates, and lipids. Various pathological conditions and environmental and chronic diseases have been associated with...

Resource Type:

Dissertation

Full Text:

Abstract approved: ______________________________________________________ Claudia S. Maier
Hydrogen/deuterium exchange mass spectrometry as a technology platform for studying conformational dynamics in large protein complexes

Creator:

Nirudodhi, Sasidhar N.

Abstract:

Proteins are essential to all biological systems. Proteins participate in numerous cellular processes by interacting with other proteins, other metabolites and membranes in a dynamic environment. Studying the structural and conformational properties of proteins in the solution phase is necessary to understand their protein folding and interaction dynamics. This research...

Resource Type:

Dissertation

Full Text:

Conformational Dynamics in Large Protein Complexes Abstract approved: Claudia S. Maier Proteins are essential