Index Catalog // ScholarsArchive@OSU

Start Over

Filtering by: Creator Chagani, Sharmeen Subject Melanoma

Regulation of Redox Homeostasis in Skin Cells for the Prevention of UV-Induced Stress and Treatment of Melanoma

Creator:

Carpenter, Evan L.

Abstract:

Melanocytes are dendritic, pigment-producing cells located in the skin and are responsible for its protection against the deleterious effects of solar ultraviolet radiation (UVR), which include DNA damage and elevated reactive oxygen species (ROS). They do so by synthesizing photoprotective melanin pigments and distributing them to adjacent skin cells (e.g.,...

Resource Type:

Dissertation

Full Text:

and acquired the funding for the project. Chapter 3: Evan Carpenter, Dr. Sharmeen Chagani, and Dr
The role of keratinocytic RXRα in regulating melanocyte homeostasis and carcinogen induced melanomagenesis, The role of keratinocytic RXR[alpha] in regulating melanocyte homeostasis and carcinogen induced melanomagenesis

Creator:

Hyter, Stephen D.

Abstract:

Cutaneous melanoma remains the deadliest form of skin cancer, with a diagnosis of metastasis indicating a median survival rate of less than a year. Solar ultraviolet (UV) radiation, especially childhood sun exposure, is an important etiological risk factor of melanoma. Previous studies determined that mice selectively lacking the nuclear hormone...

Resource Type:

Dissertation