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Filtering by: Subject Melanoma -- Etiology

Role of Melanocytic Vitamin D Receptor (VDR) in UVB-induced Melanocyte Homeostasisand Keratinocytic Retinoid–X-Receptor α (RXRα) in UVB Induced Melanomagenesis

Creator:

Chagani, Sharmeen

Abstract:

Cutaneous melanoma remains the deadliest form of skin cancer arising from malignant transformation of pigment-producing melanocytes, with a diagnosis of metastasis indicating a median survival rate of less than a year. Solar ultraviolet (UV) radiation, especially childhood sun exposure, is an important etiological risk factor of melanoma. This DNA damage...

Resource Type:

Dissertation
Roles for retinoid-X-receptors in solar UV-induced melanocyte homeostasis and melanomagenesis

Creator:

Coleman, Daniel J.

Abstract:

Melanoma is the deadliest form of skin cancer, arising from malignant transformation of pigment-producing melanocytes. The primary risk factor for melanoma and other skin cancers is DNA damage resulting from unprotected solar ultraviolet radiation (UVR). If incorrectly repaired, this damage can result in incorporation of mutations that cause aberrant cell...

Resource Type:

Dissertation