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Filtering by: Subject Nucleic acids -- Structure Subject Nucleic acids -- Analysis

Analysis of secondary structures in nucleic acid binding proteins and nuclear magnetic resonance investigation of helix propagation and residual motions in proteins

Creator:

Hicks, Joshua M.

Abstract:

This thesis involves analyses of 3₂-helices, a-helices and of the change in residual entropy of a protein upon chemical modification. Part of the long-term goal of understanding the formation, function and stability of proteins requires that all conformations be accurately assigned and structurally understood. By a statistical analysis of 258...

Resource Type:

Dissertation

Full Text:

homeodomain all contain left-handed hclices involved in nucleic acid interactions. In each structure these
The effects of pH on the torsional flexibility of DNA bound to a nucleosome core particle

Creator:

Winzeler, Elizabeth A.

Abstract:

The effects of pH on the torsional flexibility of DNA bound to a nucleosome core particle were investigated by studying the time-resolved fluorescence anisotropy decays of ethidium bromide intercalated into the DNA of the core particle. As the torsional flexibility of DNA is affected by the presence of an intercalating...

Resource Type:

Masters Thesis

Full Text:

, periodically twisted around globular proteins in a linear array, is somehow coiled into the ordered structure