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Filtering by: Creator Kuriyama, Y. Subject Polycyclic aromatic hydrocarbons -- Toxicology

Utilization of the Zebrafish Model for Investigating Nitrated Polycyclic Aromatic Hydrocarbon Developmental Toxicity

Creator:

Chlebowski, Anna C.

Abstract:

Polycyclic aromatic hydrocarbons (PAHs) are among the most widely known and studied environmental contaminants, originating from a range of natural and anthropogenic sources. PAHs are known to occur in the environment as complex mixtures, containing both unsubstituted PAHs, as well as a range of PAH derivatives. Among the less-studied of...

Resource Type:

Dissertation

Full Text:

; 12 Ramesh et al., 2004; Shimada and Fujii-Kuriyama, 2004). These DNA adducts, if not repaired
DNA binding and beyond : an investigation of proteins involved in PAH-induced carcinogesesis

Creator:

Hooven, Louisa Ada

Abstract:

Exposure to polycyclic aromatic hydrocarbons such as benzo[a]pyrene (B[a]P) has been determined to be a risk factor for various forms of human cancer. PAH DNA adducts have been shown to cause mutations, but carcinogenesis is also accompanied by alterations in gene expression. Inhibiting individual cytochrome P450s could clarify the interaction...

Resource Type:

Dissertation
Translational Studies of the High Molecular Weight Polycyclic Aromatic Hydrocarbon, Dibenzo[ def,p] Chrysene; Carcinogenesis and Metabolism

Creator:

Madeen, Erin

Abstract:

The objective of this work is to add to the body of translational data between high dose animal model research and the environmentally relevant human metabolism of the persistent pollutant dibenzo[def,p]chrysene (DBC). We furthered the knowledge of gene/exposure interactions by determining the carcinogenesis risk based on Cyp1b1 genotype following in...

Resource Type:

Dissertation