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Filtering by: Creator Karas, Michael Remove constraint Creator: Karas, Michael Subject Proteomics Remove constraint Subject: Proteomics

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  • Proteomic approach to the analysis of DNA-binding proteins using mass spectrometry

    Creator:
    Stapels, Martha Degen
    Abstract:
    In proteomic studies, separate experimental protocols have been necessary to identify proteins, determine their function, and predict their three-dimensional structure. In this study, a function-based separation of proteins was conceived to fractionate proteins prior to enzymatic digestion. In the initial demonstration of this technique, a DNA substrate was used to...
    Resource Type:
    Dissertation
    Full Text:
    academic committee: Dr. Michael Schuyler, Dr. James Ingle, Dr. Kevin Gable, and Dr. George Pearson. I

  • Tandem mass spectrometric analysis of protein and peptide adducts of lipid peroxidation-derived aldehydes

    Creator:
    Wu, Jianyong
    Abstract:
    The adduction of proteins and other biomolecules by electrophilic lipid peroxidation products such as 4-hydroxy-2-nonenal (HNE), 4-oxo-2-nonenal (ONE), malondialdehyde (MDA) or acrolein (ACR) is thought to be an initiating and/or propagating factor in the pathophysiology of several diseases such as atherosclerosis, diabetes, Alzheimer's, Parkinson's and other age-related disorders. The identification...
    Resource Type:
    Dissertation
    Full Text:
    MS/MS analysis were performed to confirm the adduct type and the modification sites. Michael